CSI use chromatography to find out what type of pen a letter or note as written with. For example if you were given a letter with three possible pens it could of been written with nowadays it would just be tested in a machine. But before machines they had to do it the long way.
What you would do is take ink from the letter and put it on a strip of paper. Then put a tiny bit of water in a beaker and wait to see what pattern it left. After this you would draw a line 2 cm from the bottom of a strip of paper. Put three equally spaced crosses on the line then put a small dot from each pen on the crosses. You would get another beaker and fill it bellow the ink line with water and then wait to the pattern the each pen left. You would then match the ink from the letter and the ink from the pen up to find which pen it was wrote with.